ALTEPLASE (AL te plase) can dissolve blood clots that form in the heart, blood vessels, or lungs after a heart attack. This medicine is also given to improve recovery and decrease the chance of disability in patients having symptoms of a stroke.
This medicine is for injection into a vein. It is given by a health care professional in a hospital or clinic setting.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark-brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eye, gums, or nose
signs and symptoms of a stroke such as changes in vision; confusion; trouble speaking or understanding; severe headaches; sudden numbness or weakness of the face, arm, or leg; trouble walking; dizziness; loss of balance or coordination
slow or fast heart rate
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
Do not take this medicine with any of the following medications:
This medicine may also interact with the following medications:
antiinflammatory drugs, NSAIDs like ibuprofen
aspirin and aspirin-like medicines
blood thinners, like warfarin, heparin or enoxaparin
This does not apply.
This does not apply. You will not be given this medicine to store at home.
They need to know if you have any of these conditions:
bleeding problems or problems with blood clotting
blood vessel disease or damaged blood vessels
head injury or tumor
high blood pressure
recent biopsy or surgery
an unusual or allergic reaction to alteplase, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Your condition will be monitored carefully while you are receiving this medicine. Follow the advice of your doctor or health care professional exactly. You may need bed rest to minimize the risk of bleeding.
This medicine can make you bleed more easily. This effect can last for several days. Take special care brushing or flossing your teeth.
Do not take aspirin, ibuprofen, or other nonprescription pain relievers during or for several days after alteplase treatment unless otherwise instructed by your doctor or health care professional.
You may feel dizzy or lightheaded. To avoid the risk of dizzy or fainting spells, sit or stand up slowly, especially if you are an older patient.
The University of Chicago Medicine
5841 S. Maryland Avenue
Chicago, IL 60637 | 773-702-1000
Appointments: Call UCM Connect at 1-888-824-0200