Goodpasture syndrome is a group of acute illnesses that affects the lungs and kidneys. It involves an autoimmune disorder. Normally, the immune system makes antibodies to fight off germs. But with Goodpasture syndrome, the immune system mistakenly makes antibodies that attack the lungs and kidneys. This condition can quickly progress to an inflammation of the kidneys (glomerulonephritis) and kidney failure. It can be fatal if not quickly diagnosed and treated.
This disease most often occurs in people ages 20 to 30 or those older than age 60. It is more common in men. In some cases, bleeding in the lungs may occur. In most cases, this disease does not cause lasting damage to the lungs. But kidney damage may be long-lasting. If the kidneys fail, kidney transplant or dialysis may be needed.
Medical experts are not certain what causes this disease. It can run in families, so genetics may play a role. Or the disease may occur because of a combination of other factors. These include exposure to certain chemicals, such as dry cleaning chemicals or the weed killer Paraquat. Viral infections, smoking, or medicines may also play a role.
These are the most common symptoms of Goodpasture syndrome:
As the condition progresses, other symptoms may occur, including:
Over time, symptoms of kidney involvement may occur, including:
The symptoms of Goodpasture syndrome may look like other conditions or medical problems. Always see your healthcare provider for a diagnosis.
Your healthcare provider will review your health history and do a physical exam. Other tests include:
Your healthcare provider will figure out the best treatment for you based on:
Treatment may include:
Even with proper treatment, complications may develop. Your kidney function may decrease to the point of kidney failure. This can require treatment such as dialysis or even a kidney transplant.
Tips to help you get the most from a visit to your child’s healthcare provider:
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