EZETIMIBE; SIMVASTATIN (ez ET i mibe; SIM va stat in) blocks the body's ability to absorb and make cholesterol. It is used to lower cholesterol. It is only for patients whose cholesterol level is not controlled by diet.
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine in the evening with or without food. Take your doses at regular intervals. Do not take your medicine more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 10 years, precautions do apply.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
dark yellow or brown urine
loss of memory
muscle pain, tenderness, cramps, or weakness
redness, blistering, peeling or loosening of the skin, including inside the mouth
trouble passing urine or change in the amount of urine
unusually weak or tired
yellowing of the skin or eyes
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
Do not take this medicine with any of the following:
certain antibiotics like clarithromycin, erythromycin, and telithromycin
certain antiviral medicines for HIV or AIDS
medicines for fungal infections like itraconazole, ketoconazole, posaconazole, and voriconazole
red yeast rice
This medicine may also interact with the following medications:
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Keep out of the reach of children.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.
They need to know if you have any of these conditions:
frequently drink alcoholic beverages
kidney or liver disease
muscle aches or weakness
other medical condition
an unusual or allergic reaction to ezetimibe, simvastatin, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Visit your doctor or health care professional for regular check-ups. You may need regular tests to make sure your liver is working properly.
Tell your doctor or health care professional right away if you get any unexplained muscle pain, tenderness, or weakness, especially if you also have a fever and tiredness. Your doctor or health care professional may tell you to stop taking this medicine if you develop muscle problems. If your muscle problems do not go away after stopping this medicine, contact your health care professional.
This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.
This drug is only part of a total heart-health program. Your doctor or a dietician can suggest a low-cholesterol and low-fat diet to help. Avoid alcohol and smoking, and keep a proper exercise schedule.
Do not use this drug if you are pregnant or breast-feeding. Serious side effects to an unborn child or to an infant are possible. Talk to your doctor or pharmacist for more information.
If you are going to have surgery tell your health care professional that you are taking this drug.
Some drugs may increase the risk of side effects from this medicine. If you are given certain antibiotics or antifungals, your doctor or health care professional may stop this medicine for a short time. Check with your doctor or pharmacist for advice.
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